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Prolyl hydroxylase
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Wikipedia
Prolyl hydroxylase (or procollagen-proline dioxygenase) is an enzyme involved in the production of collagen, acting to hydroxylate proline to hydroxyproline.
It requires vitamin C as a cofactor.
Reaction: Proline + α-ketoglutarate + O2 + Fe2+ → 4-hydroxyproline + Fe4+ + CO2 + succinate
The process requires ascorbic acid which provides Fe2+as a reductant to provide two electrons.
It is classified under .
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This article is licensed under the GNU Free Documentation License.
Last updated on Thursday May 15, 2008 at 17:38:08 PDT (GMT -0700)
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This article is licensed under the GNU Free Documentation License.
Last updated on Thursday May 15, 2008 at 17:38:08 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
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