At Villanova, Arizin made the team in his sophomore year, and progressed so rapidly that in 1950 he was named the collegiate player of the year after leading the nation with 25.3 points per game. During a game in 1949, Azirin scored 85 points against the Naval Air Materials Center roster. After being selected by the Warriors with their first pick in the 1950 NBA Draft, he was the league scoring champion during the 1951-52 and 1956-57 seasons, and became one of the greatest NBA players of the 1950s.
He became famous for his line-drive jump shots, and teamed with center Neil Johnston to form the best offensive one-two punch in the NBA at the time, leading the Warriors to the 1956 NBA title. He also played with scoring star Joe Fulks early in his career, and with Philadelphia legends Tom Gola and Wilt Chamberlain toward the end of his career in the early 1960s. Arizin chose to retire from the NBA rather than move with the Warriors to San Francisco. At the time of his retirement, no player had retired from the game with a higher scoring average (21.9 points per game) in his final season. This record would stand until Bob Pettit's retirement in 1965 following a season in which he averaged 22.5 PPG.
Arizin played in 10 NBA All-Star Games (he was the 1952 NBA All-Star Game MVP) and was named to the All-NBA First-Team in 1952, 1956, and 1957. He was inducted into the Basketball Hall of Fame in 1978. He died in his sleep at age 78 on December 12, 2006, in Springfield, Pennsylvania.