The Otselic River (aht-SEEL-ik) is a tributary of the Tioughnioga River, approximately 45 mi (72 km) long, in central New York in the United States. It drains a mountainous area, mostly forested and agricultural, east of the Finger Lakes at the northern edge of the Susquehanna River watershed.

It rises in southwestern Madison County, northeast of Georgetown, and flows southwest, past Georgetown, Otselic, and Cincinnatus. It joins the Tioughnioga River from the northeast at Whitney Point, where it is impounded to form Whitney Point Lake.

See also

• List of New York rivers