This phenomenon likely results from changes in NMDA receptors in the dorsal horn of the spinal cord. Research on the mechanisms underlying this phenomenon is ongoing, as are attempts to identify NMDA receptor antagonists, which may be able to prevent or attenuate this effect.
If an individual is taking opioids for a chronic non-cancer pain condition, and requires increasing doses, yet still do not achieve pain relief, they may be experiencing opioid-induced hyperalgesia. If so, they may benefit from complete withdrawal from opioid therapy. Many individuals report reduced pain levels when opioids are withdrawn.
WIPO PUBLISHES PATENT OF LABORATORIOS DEL DR. ESTEVE FOR "USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA" (SPANISH INVENTORS)
Feb 10, 2012; GENEVA, Feb. 10 -- Publication No. WO/2012/016980 was published on Feb. 09. Title of the invention: "USE OF SIGMA LIGANDS IN...