Having studied at the Strasberg Institute, the blonde, raspy-voiced Blackwood acted in a number of TV show and films, making appearances in the 1982 movie Vice Squad, Revenge of the Stepford Wives, and the 1993 film Reckless Kelly. She also was with the 2003 road company of The Vagina Monologues.
Long before she became well-known as a performer, Blackwood appeared naked in the August 1978 Playboy pictorial "Girls of the Office.
She was chosen for MTV's original video jockey lineup, along with Martha Quinn, Mark Goodman, Alan Hunter, and J. J. Jackson. After leaving the music video network in 1986, she hosted her own "Rock Report" for Entertainment Tonight. She also hosted the TV music show Solid Gold from 1986-1988. Blackwood has since appeared on A Current Affair, Access Hollywood, VH1, The Discovery Channel, and MSNBC.
In 1999, Blackwood and longtime manager/producer Danny Sheridan launched a nationally syndicated radio show for Dick Clark's United Stations Radio Network, Nina Blackwood's Absolutely 80's. The two followed up with the another nationally syndicated program, the 80's alternative-themed Nina Blackwood's New Wave Nation. Blackwood currently hosts a weekday air shift (1-6 p.m. Eastern/10 a.m.-3 p.m. Pacific), and on weekends, The Big '80s Top 40 Countdown for Sirius Satellite Radio's Big '80s. (Coincidentally, all of the other original surviving MTV VJs are also working for Sirius.)