Necrolytic migratory erythema
(NME) is a classical symptom observed in patients with glucagonoma
and is present in 80% of cases.
Associated NME is characterized by the spread of erythematous
blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
It consists of serpiginous (slow progressing) erythematous plaques. Where the migratory edge has an "eroded" appearance.
It usually starts in the Perineum. Weight loss, anaemia , mild diabetes, diarrhoea and glossitis are associated. Liver metastasis is often present.