Mouse hepatitis virus (MHV) is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice. Prior to the discovery of SARS-CoV, MHV had been the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection.(Short report)(Clinical report)
Jun 07, 2007; Authors: Matthijs Raaben ; Alexandra WC Einerhand ; Lucas JA Taminiau ; Michel van Houdt ; Janneke Bouma ; Rolien...