Simpson went on to compose the scores for the films Road Trip, Saving Silverman, Freddy Got Fingered and, most recently Stick It where in addition to composing the original score, he teamed up with rapper Talib Kweli to produce and perform the song "Abra Cadabra". He has also contributed original music and songs to such films as Zoolander and The Spongebob Squarepants Movie.
Simpson is the musical director and frequent guest of Tom Green Live, Tom Green's live Internet show. In addition, E.Z. Mike and Tom Green created the Keepin' It Real Crew who recorded the album Prepare for Impact released by Sony Records in 2006.