As a result of the murders, Logan waged war on the settlements along the Ohio and in western Pennsylvania, killing, perhaps, nearly thirty men, women and children. Lord John Murray Dunmore, the British Royal Governor of Virginia, raised an army and appointed Cresap to the rank of captain. The decisive battle of Dunmore's War was the Battle of Point Pleasant. Here Dunmore's forces defeated a band of Shawnee Indians led by Cornstalk.
After Lord Dunmore's War, Cresap returned to Maryland and subsequently raised a company of riflemen for the Continental Army during the American Revolution. He died from illness in New York City while in the service of the army; he is interred there in Trinity Church Cemetery.