The first part of the Metamorphosis Odyssey was printed in the premier issue of Epic Illustrated magazine, which was published in the Spring of 1980. The story was told in fourteen chapters and continued through the first nine issues of Epic Illustrated, climaxing in the December 1981 issue. The stories were initially in black and white but later transitioned into full color. The story continues in two graphic novels and finally a long running comicbook series.
As the Zygotean power only grew, and the Zygoteans conquered, enslaved, and exterminated more and more of the Milky Way, the Osirosians eventually concluded that they were not capable of stopping the Zygoteans, and that therefore the Milky Way was doomed to a long, slow, horrible death. Aknaton, unwilling to let the Milky Way be slowly strangled by the Zygoteans, evolved a plan to destroy the Zygoteans, whatever the cost. Running the Zygotean blockade of his homeworld, Aknaton set various events in motion to mature over time into the elements he needed for his final plan. The most important actions he took were:
Having done all these things, he returned to his homeworld and waited for the last stand. The Osirosians held out for a hundred thousand years, but in the end the Zygoteans overcame their defenses and destroyed them. Armed with all his race's power and his plan, Aknaton escaped, the only survivor.
Aknaton returned to the worlds he had visited a hundred thousand years previously, taking a single native from each one to fulfill their part in the plan: Za, the first of his cannibal race to achieve intelligence; Juliet, a fifteen-year-old girl from Kansas; and Whis'Par, the culmination of the artificial life Aknaton had created on the forest world.
Having gathered the three he needed, Aknaton returned to Byfrexia, where the icy sword had been found by a young Byfrexian named Vanth, who stumbled across it in the Arctic wilderness after ice bears devoured his family. The power of the sword preserved Vanth's life. In time, he came to find that it had other powers as well; it could absorb energy of almost any type and later redirect it as a destructive force; it gave Vanth great toughness and physical strength; it gave him the gift of tongues; and he was able to merge with the sword in a way unforeseen even by its maker, so the sword became a part of him that he could manifest at will. Vanth became obsessed with revenge, and spent many years hunting his world's ice bears nearly to extinction. The other Byfrexians, who depended on the bears for food, eventually leagued against Vanth and drove him offworld, where he spent some unspecified time as a mercenary. When the Zygoteans attacked Byfrexia, Vanth returned home and led resistance to them, becoming known as "The Cold Man."
Aknaton found Vanth and recruited him to be his pilot and bodyguard. Vanth leapt at the chance that there might be a plan to destroy the Zygoteans; though he was shaken when Aknaton revealed the exact nature of the plan to him and the others.
Aknaton had reasoned that since the Zygoteans were undefeatable, and the death of the galaxy could not be prevented, the only remaining kindness was to make the end as quick and painless as possible. He therefore created the Infinity Horn...whose purpose was to destroy the entire Milky Way. Appalled, but convinced that Aknaton's plan was the only option, Vanth and the others agreed. Fighting their way past an army of Zygoteans and their slaves (who had become aware of the plan and fought desperately to stop it), they returned to the cavern on the planet Dreamsend. As Aknaton and Vanth held off the Zygoteans outside, Za, Juliet, and Whis'Par entered the cavern and sounded the Infinity Horn, destroying the entire Milky Way in an instant.
The three who sounded the Horn were transformed into a new kind of being, carrying with them all that remained of the Milky Way, except for Aknaton and Vanth. Aknaton had used his mystic powers to encase himself and Vanth in a bubble of force and throw them into intergalactic space.
Eons later they crashed on a planet in another galaxy, where Vanth shot Aknaton in a fit of rage and guilt over the destruction of the Milky Way galaxy. Mortally wounded, Aknaton confessed that he had goaded Vanth into killing him because he could not live with the guilt. As he died, he told Vanth that he had saved him and brought him here because this galaxy was at a point where it might go down the same path as the Milky Way. Aknaton wanted Vanth to change the destiny of this new galaxy, and if he failed, to then locate the Infinity Horn to destroy this galaxy as well.
This graphic novel opens with Vanth Dreadstar leading the life of a peaceful farmer. The planet on which he lived was the site of an Instrumentality experiment to create a race of cat-human hybrid warriors. The experiment was a failure, the hybrids were mild-natured and generally only suited to farming. Dreadstar married a human scientist and lived quietly for some decades, but this ends shortly after the arrival of Darklock when a fleet of Monarchy ships destroys his home village, killing his wife and all his friends.
The ground they gained in the Monarchy is lost when the Monarchy is betrayed from within by a high minister (who turns out to be the last surviving Zygotean, who was in intergalactic space when the Infinity Horn destroyed the Milky Way, and who followed Akhnaton's mystic escape pod in hopes of revenge.) The Monarchy is overthrown, and the war ends, but not in the way anyone wanted. The Instrumentality conquers the galaxy and begins a campaign of extermination, apparently following the will of their evil Twelve Gods. Vanth and his crew escape the ruin of the Monarchy and league with the remains of the Monarchic fleet to oppose the Instrumentality. Eventually, after various victories and defeats and escapes, Vanth and Syzygy destroy the Lord High Papal and overthrow the Instrumentality, confront the Twelve Gods, and destroy them.