She was born in Dresden, the daughter of Augustus III of Poland and Maria Josepha, herself daughter of Joseph I, Holy Roman Emperor.
In 1738, at the age of 14, Maria Amalia married Charles of Bourbon, then King of the Two Sicilies. Despite the fact that this was an arranged marriage, the couple was very close and had many children.
Maria Amalia was a very cultivated woman, and it was she who introduced the production of porcelain in Naples. She also played an important role in the construction of the Caserta Palace. She was also a heavy tobacco smoker.
In 1759, Ferdinand VI of Spain, her husband's elder half-brother, died without issue, and the couple became King and Queen of Spain. That same year they left Naples for Madrid, leaving several of their children behind in Caserta. Her third-surviving son became Ferdinand I of the Two Sicilies, while his elder brother Carlos was groomed in Spain to inherit the Spanish crown (their oldest brother, Prince Philip, Duke of Calabria, was excluded from the succession due to his mental instability).
In September 1760, a year after arriving in Madrid, Maria Amalia died from tuberculosis. Her husband, who had become Charles III commented : "In 22 years of marriage, this is the first time Amalia displeases me". He never married again.
They had thirteen children; however, only seven reached adulthood.