Smith has won the American Comedy Award for Best Female Stand Up Comedian, starred in her own special for Comedy Central and has produced and starred in her own independent projects. She has published her own CD titled As It Should Be which has a liner note from Jay Leno who writes, “The best comedians are the ones that write and perform their own material and Margaret Smith is at the top of that list”.
Her list of roles in Television and Film include parts in Martin Scorsese’s Goodfellas, the remake of The Blob, the Wachowski brothers' hit thriller Bound with Gina Gershon and Jennifer Tilly, and a guest starring role in the Pamela Anderson series, VIP.
Smith has appeared many times on both The Tonight Show with Jay Leno as well as the Late Show with David Letterman and has toured the comedy circuit doing live performances throughout the United States and beyond including Britain, Ireland and Australia.
She’s worked with everyone from Rosie O’Donnell to the late Bob Hope. She says, “Phyllis Diller told me the dirtiest joke I’ve ever heard,” and claims to have had an emotional bottom on The Oprah Winfrey Show.