The tour's opening night was on September 21, 1989 at the Entertainment Centre in Perth, Australia. The first leg took place over the next 10 weeks in Australia, New Zealand, and Japan. A brief second leg hit four countries in Europe for four weeks, ending on January 10, 1990 at the Sport Paleis Ahoy in Rotterdam, The Netherlands. Of the tour's 47 concerts, 23 were played in Australia.
B. B. King toured with the band and played the first set each night. At the end of U2's set, King and his band joined them for a short encore.
The tour was plagued by troubles with Bono's voice due to both excessive use and illness - he stated in concert that he caught "some pretty psychedelic germs" in Australia and that they were "having their Annual General Meeting" in his throat. These vocal troubles meant three Sydney concerts had to be postponed. Later, severe troubles meant a concert in Amsterdam had to prematurely conclude; two other Amsterdam shows were cancelled and replaced by four shows in Rotterdam, causing the tour to spill over into 1990 instead of ending on New Year's Eve at Dublin's Point Depot as planned. However, when Bono's voice was not troubling him, he had an impressive singing range, with the falsetto later mastered starting to seriously appear, but without sacrificing the powerful depth of his lower singing range.
As with all U2 tours from 1983 on, the stage and lighting design was done by Willie Williams. The tour name, possibly a contraction of the Rattle and Hum song "When Love Comes to Town", was the first not to be named for the band's then-current album; as of 2006, all of their subsequent tours have also had different names from any album.
This foreshadowed the abrupt directional changes the band would take in the 1990s, beginning with Achtung Baby and the Zoo TV Tour.