The people listed below were all born in, residents of, or otherwise closely associated with Demopolis, Alabama
- James Haskins (1941-2005), public school teacher and prize-winning author (See Diary of a Harlem Schoolteacher, The Cotton Club, Black Music in America, Outward Dreams: Black Inventors and Their Inventions. For younger readers, The March on Washington, Black Eagles: African Americans in Aviation).
- Michelle Richmond (November 12, 1970), Award-winning fiction writer and essayist (see The Girl in the Fall-Away Dress, Dream of the Blue Room).
- Hudson Strode (1892-1976) an influential teacher of creative writing at the University of Alabama from 1924-1964, who was honored in 1961 by King Gustaf VI Adolf of Sweden in recognition of his contributions toward strengthening the cultural relations between the United States and Sweden.
- Samuel Ginn, A pioneer in the wireless communications industry who served as chairman of Vodafone and now serves as a member of the Auburn University Board of Trustees and is the namesake for AU’s Ginn College of Engineering.
- Waldo Semon, an inductee of the Inventor Hall of Fame and the inventor of vinyl and holder of over a hundred patents, was born in Demopolis.