Leopoldina is a municipality of 53,000 in the Brazilian state of Minas Gerais.

It is situated in the southeastern Zona da Mata part of the state.

Leopoldina was the site of a wave of immigration of Jews, mostly from Eastern Europe, in the 1920s and 1930s, as detailed in a book Jews of Leopoldina, published in 2007 by the Jewish Museum of Rio de Janeiro.

The city is also the seat of the Roman Catholic Diocese of Leopoldina.

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