She made her first film in 1924, and with her blonde hair, delicate features, and good natured demeanour, was cast in a string of supporting roles, where she was required to do very little but smile and look pretty. She proved herself capable of handling the small roles she was assigned, and over a period of time she came to be taken seriously as an actress. By 1928 she was playing starring roles, achieving success in MGM's first talkie release, Alias Jimmy Valentine (1928) opposite William Haines, Lionel Barrymore and Karl Dane. The following year she appeared in the popular murder mystery The Thirteenth Chair, a role that offered her the chance to display her dramatic abilities as a murder suspect.
The quality of her parts continued to improve as the decade turned, including a role as Robert Montgomery's sister in the prison drama The Big House (1930) with Chester Morris and Wallace Beery, for which Hyams once again received positive reviews. She then appeared in Surrender (1931).
Although she succeeded in films that required her to play pretty ingenues, and developed into a capable dramatic actress in 1930s crime melodramas, she is perhaps best remembered for two early 1930s horror movies, as the wise-cracking but kind hearted circus performer in Freaks (1932), and as the heroine in Island of Lost Souls (1933). Hyams was the original choice to play Jane in Tarzan the Ape Man (1932), but turned it down. The role was ultimately played in that film and several Tarzan films by Maureen O'Sullivan.
She also appeared in the controversial Jean Harlow film Red-Headed Woman (1932), the musical comedy The Big Broadcast (1932) with Bing Crosby, George Burns and Gracie Allen, and was widely praised for her comedic performance in Ruggles of Red Gap (1935) opposite Charles Laughton and Charlie Ruggles.
After ten years and fifty films, Hyams retired from acting in 1936, but remained part of the Hollywood community for the rest of her life. She was married to the agent Phil Berg from 1927 until her death in Bel Air, California, aged 72.