Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), also known as LRP1 or CD91, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.

LRP1 and Alzheimer's disease

Neurons require cholesterol to function. Cholesterol is imported into the neuron by the apolipoprotein apoE4 via LRP1 receptors on the cell surface. It thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol.

References

See also

• Cluster of differentiation
• Low density lipoprotein receptor gene family

Further reading

External links