Reinders originated the role of Glinda in the 2005 Chicago production of Wicked, alongside Ana Gasteyer as Elphaba; for this role, she received a Joseph Jefferson Award nomination for Best Actress in a Principal Role. She and Gasteyer finished their runs in the Chicago company on January 22, 2006. Reinders' replacement was former Broadway Glinda standby, Stacie Morgain Lewis. Later that year, on May 30, 2006, she replaced Megan Hilty as Glinda in the Broadway production. While doing this role she performed "Popular" in a Daily Double about "Wicked" on an all-celebrity episode of Jeopardy!. TV personality Nancy Grace gave the correct question. She ended her run on January 7, 2007 along with Derrick Williams and former Chicago co-star, Ana Gasteyer. Reinders was replaced by Kendra Kassebaum, the original Glinda of the 1st national tour of Wicked.
Reinders is also a member of the band Tastiskank, along with another Broadway actress, Sarah Litzsinger.
Reinders was part of the cast in the show "Party Come Here", which ran as part of the Williamstown Theatre Festival from July 25 through August 5, 2007.
She recently appeared in the play The Fabulous Life of a Size Zero, Off-Broadway at the DR2 Theater.
Reinders and Litzsinger will co-star opposite Constantine Maroulis in an idependent TV pilot called Teachers which will air at the fourth annual New York Television Festival.
Reinders also has a recurring role as a character named Ginger on the third season of Ugly Betty.