In 1893, Fisher finished his law degree, was admitted into the Pennsylvania Bar, and set up a private practice. He won his first major office, to the Pennsylvania State Senate, in 1901, where he served until 1909. Thereafter he would serve on the state's Commission on Constitutional Revision, and from 1919-1922 as State Commissioner of Banking. He rose to the Governor's office in 1927.
As governor, Fisher focused on fiscal policy, public works, and conservation. Partly due to his efforts to eliminate voting fraud, the state began using voting machines. The Department of Revenue was established during his term. Fisher's term was marked by a major investment in public works, most notably the Soldiers and Sailors Memorial Bridge. Also during Fisher’s administration, nearly were added to Pennsylvania’s state forests.
After leaving office, Fisher became a consultant to his son’s law firm. He would also serve on the boards of several financial establishments as well as Indiana Hospital, the State Normal School in Indiana, PA, and Pennsylvania State College.