John Scott (father of Pennsylvania Senator John Scott (1824-07-24 – 1896-11-29) and of the 1868 candidate for Governor of Florida, George W. Scott) was born at Marsh Creek, near Gettysburg, Pennsylvania. He moved to Alexandria, Pennsylvania, in 1806 and was engaged as tanner and shoemaker. He served as major in the War of 1812. He was a member of the Pennsylvania House of Representatives in 1819 and 1820.
Scott was elected as a Jacksonian to the Twenty-first Congress. He was an unsuccessful candidate for reelection to the Twenty-second Congress. He resumed his former business pursuits and retired from business in 1842. He died in Alexandria, Pennsylvania in 1850. He was interred in Alexandria Cemetery.