In the late 21st Century, Spacely Sprockets and Spindles has opened a new mining colony on an asteroid. The proposed project is meant to produce product at 1/10 the cost of making the items on Earth. However, the factory continues to be plagued with problems, and as Mr. Cosmo Spacely checks up on the 'Orbiting-Ore Asteroid' again, the latest head of the factory, Mr. Alexander Throttlebottom, has left his post, making it 4 managers of the new plant that Spacely's lost so far.
Fearing for his company (and profits), Mr. Spacely names George Jetson as Throttlebottom's successor and sends George and his family to the factory. While the family is thoroughly upset from having to have been thrown from their normal life style (and the plans that they had that day), they set up apartments on the adjoining apartment community to the Asteroid and its neighboring shopping complex. While it takes the family time to adjust, Elroy befriends a robot boy named Teddy-2, whose father, Rudy-2, shows George around the plant. Judy Jetson, meanwhile, is having a hard time adjusting, and accepting the fact that she lost her chance at a date with a rock star, but soon feels better meeting a teenage boy named Apollo Blue.
George soon figures he's ready to set the plant running again, and Mr. Spacely is all set to see the plant working full-throttle, and soon to churn out the 1,000,000th Spacely Sprocket. However, the opening day festivities give way to panic as the factory soon malfunctions once again. Over the next several days, George and Rudy-2 try to fix things, but the problems persist, to the point that Mr. Spacely heads on up to check on things.
Thinking he has to take charge, George stays overnight, only to be taken off by a furry alien race known as the Grungees. Elroy and Teddy-2 sneak into the factory, and meet a little Grungee named Squeak, who tells them that the factory is actually drilling into their community, which is based inside the asteroid. Soon, Judy, Apollo Blue, and Jane show up, and realize what is happening as well. George is found in the Grungee's colony, and soon realizes just what the factory is doing.
But Mr. Spacely doesn't. Seeing his factory at a stand-still, he starts it up, nearly burying Elroy and Squeak alive under rubble, and prompting everyone in the asteroid to get top-side, where George manages to shut-down the factory, and show his boss exactly what he's doing. After some talk, they come to an agreement: The Grungees will run the plant, and create new Spacely Sprockets through recycling old ones (thus stopping the further destruction of the Grungee's homeworld). Soon after, Spacely Sprockets reaches the 1,000,000th sprocket, and Mr. Spacely figures that George is no longer needed at the Asteroid.
And so, the Jetsons bid their new friends a tearful goodbye, and head back to their apartment on Earth. The Grungees arrange themselves on the outside of the asteroid to say "THANK YOU GEORGE" as a final grateful goodbye to George for saving their home.
Tiffany sang three songs used in the film ("I Always Thought I'd See You Again", "You and Me", and "Home"), which are on the soundtrack album along with "Jetsons' Rap" by XXL and tracks by other artists.
The film was finally released to theaters on July 6, 1990, and was not a box office success. It performed better on home video, and was routinely broadcast on television. Jetsons: The Movie has not been issued on DVD in North America, although it aired in widescreen HD (the first time the film was presented in its original aspect ratio for home audiences) on Universal HD on February 2, 2007.
The film has been released on DVD in Region 4
and Region 2 
Cartoon Network shows this film irregularly, even though the original series is no longer broadcast on the network. The series can instead be found on its sister channel, Boomerang.
Wendy's restaurant chain had a Jetsons kids' meal tie-in. When clips from the film were shown on TV, scenes with George had re-dubbed lines from an unnamed voice actor. The commercials showed Wendy's founder Dave Thomas either in a theater watching the film, or at his restaurant promoting the film.
In 1991 in video game a Jetsons video game was released for the Super Nintendo Entertainment System that involved elements of both the television show and film
A tie-in simulator ride titled The Funtastic World of Hanna-Barbera opened with Universal Studios Florida shortly prior to the films release. In it, Joe Barbera and Bill Hanna state that Elroy Jetson will star in their next project (presuming the film), which angers Dick Dastardly and Muttley and causes them to kidnap Elroy, and Yogi Bear must save him. Merchandise based on the film was sold at the ride's gift shop.