This deal led to Elfman's starring role in the sitcom Dharma & Greg, which ran on ABC from 1997 to 2002. She won a Golden Globe Award for this role, and was nominated twice for an Emmy Award. In 1999, she co-hosted the Emmy Awards presentation with David Hyde Pierce.
In November 2005, CBS announced that the Elfman vehicle, Courting Alex would be a midseason replacement, premiering in January 2006. It was announced in May that the show did not get picked up, and was thus cancelled. However, CBS immediately inked a new development deal with Elfman to create a comedy vehicle, as reported in The Hollywood Reporter on June 2, 2006.
Jenna's other television appearances include guest starring roles in two episodes of Two and a Half Men in 2004 and one episode of Brothers and Sisters in 2007.
Jenna will guest star on the fourth season premiere of My Name Is Earl as a cheer team leader.
Elfman's other film credits include Krippendorf's Tribe, Looney Tunes: Back in Action, and Town & Country.
She is in a yet to be released film with Tim Allen entitled The Six Wives of Henry Lefay.
In 2005, she appeared at the Church of Scientology-affiliated Citizens Commission on Human Rights' controversial "Psychiatry: An Industry of Death museum grand opening and is described on the organization's website as a supporter.
In May 2006, Elfman visited her high school alma mater to urge students to set career goals and encourage them to persist in their chosen professions.
In January 2007, Elfman and her husband announced they were expecting their first child. On July 23, 2007, the couple welcomed son, Story Elias, in Los Angeles, weighing 7 pounds, 2 ounces.
On May 24, 2006, she was the keynote speaker at the Human Rights Hero Award event in participation with the Scientology-affiliated groups Youth for Human Rights International and Artists for Human Rights (AFHR), an organization formed with the purpose of bringing artists together with the common cause of raising awareness of human rights around the world. The event took place in Washington, D.C. and was attended by members of Congress and the general public. Awards were presented to individuals who through their actions have brought about greater human rights.
Elfman donated her lip print for a limited edition U.S. postage stamp created by Zazzle to celebrate Valentine's Day in both 2007 and 2008. Proceeds for the "Kiss Stamps" went to support the programs of The Humane Society of the United States (HSUS).
On March 27, 2008, she and Charlie Sheen co-hosted the "New York Rescue Workers Detoxification Project" Charity Event at Geisha House in Hollywood, California.
As a criminal rehabilitation activist, Elfman has traveled to Washington D.C. to lobby for criminal reform. On April 5, 2007, she was awarded with the Goodwill Ambassador Award for her work in human rights and criminal rehabilitation at the Women Ambassadors Foundation 12th Annual Conference. On April 9, 2008, she was a guest at the signing of a new bill by U.S. President George W. Bush that aims to reduce prisoner recidivism, entitled the Second Chance Act of 2007 ().
| Year | Film | Role | Other notes |
|---|---|---|---|
| 1997 | Grosse Pointe Blank | Tanya | |
| 1998 | Dr. Dolittle | Owl | voice |
| Can't Hardly Wait | The Angel | uncredited | |
| Krippendorf's Tribe | Prof. Veronica Micelli | ||
| 1999 | EDtv | Shari | |
| Venus | Venus | ||
| 2000 | The Tangerine Bear | Lorelei | voice |
| CyberWorld | Phig | voice | |
| Keeping the Faith | Anna Riley | ||
| 2001 | Town & Country | Auburn | |
| 2003 | Looney Tunes: Back in Action | Kate | |
| 2004 | Clifford's Really Big Movie | Dorothy | voice |
| 2005 | Touched | Angela Martin | also Executive Producer |
| What's Hip, Doc? | Supermodel | voice | |
| 2008 | Struck | ||
| The Six Wives of Henry Lefay | Ophelia | post-production | |
| Hanging Out Hooking Up Falling in Love | Darlene | filming | |