In 1950, Crain starred opposite Myrna Loy and Clifton Webb in Cheaper by the Dozen. Next, Crain paired up with Cary Grant, for the Joseph L. Mankiewicz production of People Will Talk (1951). Crain was again teamed with Loy in Belles on Their Toes (1952), the sequel to Cheaper by the Dozen.
While still at Fox, Crain gave an excellent performance as a young wife quickly losing her mind amidst high seas intrigue in Dangerous Crossing, co-starring Michael Rennie. Crain then starred in a string of pictures for Universal Pictures, including notable pairings with Kirk Douglas, such as Man Without a Star (1955).
Also in 1955, Crain also showed off her lively dancing abilities in Gentlemen Marry Brunettes, co-starring Jane Russell, Alan Young, and Rudy Vallee. The production was filmed on location in Paris and Crain's singing in the film was dubbed, as was customary. The film was based on the Anita Loos novel that was a sequel to her acclaimed Gentlemen Prefer Blondes. Gentlemen Marry Brunettes was popular throughout Europe at the time and was released in France as A Paris Pour les Quatre ("To Paris For The Four"), and in Belgium as Cevieren Te Parijs. Later in the 1950s, Crain, Russell, and another actress teamed up for a short-lived singing and dancing lounge act at one of the hotels on the Las Vegas Strip.
In 1956, Crain starred opposite Glenn Ford, Russ Tamblyn, and Broderick Crawford in the compelling Western, The Fastest Gun Alive. The film was directed by Russell Rouse. In 1957, she was a socialite who helps a crushed singer (Frank Sinatra) redeem himself in The Joker Is Wild.
In 1959, Crain appeared in a prestigious CBS Television special production of Meet Me in St. Louis. Also starring in the broadcast were Myrna Loy, Walter Pidgeon, Jane Powell, and Ed Wynn. However, top billing on the program went to co-star Tab Hunter.
Film roles became fewer in the 1960s as Crain went into semi-retirement. Crain was captivating as Nefertiti in the Italian production of Queen of the Nile (1961) with Edmund Purdom and Vincent Price. During this period Crain did a stint as one of the What's My Line? Mystery Guests on the popular Sunday night CBS-TV program. She also starred again with Dana Andrews in Hot Rods To Hell (1967). Crain's last film role was in Skyjacked (1972).
As a lifelong devout Roman Catholic, Jeanne Crain Brinkman and her husband Paul remained married, though they lived separately in Santa Barbara, California, until Brinkman's death in October 2003. Crain died a few months later and it was later confirmed that the cause was a heart attack. Crain's funeral Mass was held at the Old Santa Barbara Mission. Crain is buried in the Brinkman family plot at Santa Barbara Cemetery. The couple outlived two of their children. The Brinkmans were survived by five adult children, including Paul Brinkman Jr., a successful television executive, most known for his work on CBS TV's JAG. Crain was also survived by many grandchildren, nieces, and nephews.
Crain's eldest granddaughter, actress and singer/songwriter Bret Crain, set up a website dedicated to Crain's memory: jeannecrain.org. On the website one can read about Bret's fond memories of her grandmother. Bret Crain can be seen being interviewed on the upcoming DVD release of Jeanne Crain's "Dangerous Crossing."
Crain's career is fully documented by an extraordinary collection of memorabilia about her assembled by the late Charles J. Finlay (longtime publicist at 20th Century Fox). The Jeanne Crain collection resides perpetually at the Wesleyan University Cinema Archives in Middletown, Connecticut. These archives also hold the papers of Frank Capra, Ingrid Bergman, Clint Eastwood, and others.