Reno has starred in such high-profile American movies as French Kiss (1995) with Meg Ryan and Kevin Kline, Mission: Impossible (1996) with Tom Cruise, Ronin (1998) with Robert De Niro, and Godzilla (1998), for which Reno turned down the role of Agent Smith in the The Matrix. He has not neglected to continue making French productions either - e.g., Les Visiteurs (1993) (which was later remade in English as Just Visiting in 2001) and The Crimson Rivers (2000). In 2006, he had a prominent role in the remake of The Pink Panther, playing Gilbert Ponton, the partner of Inspector Clouseau opposite Steve Martin, and also portrayed Captain Bezu Fache in the Ron Howard film The Da Vinci Code.
In other media, Reno was involved in the production of the third installment in the popular PlayStation 2 series Onimusha (Onimusha 3: Demon Siege), lending his likeness to the protagonist, Jacques Blanc, as well as providing the voice for the character's French dialogue. Reno has also appeared in United Parcel Service advertisements on television.
Reno endorsed Nicolas Sarkozy for the 2007 French Presidential Elections. He is a huge fan of Elvis Presley and can actually imitate Elvis' voice. He used his "Thank you very much" impression in a scene of the film Godzilla when the script needed his character to pass as an American.
| Year | Title | Role | Notes | |
|---|---|---|---|---|
| 1980 | The Moroccan Stallion | |||
| 1982 | La Passante du Sans-Souci | |||
| 1983 | Le Dernier Combat | |||
| 1985 | Le téléphone sonne toujours deux fois | Marraine 's confidence man | ||
| Subway | The Drummer | |||
| 1988 | Le Grand Bleu (The Big Blue) | Enzo Molinari | ||
| 1990 | L'Homme au masque d'or | Father Victorio Gaetano | ||
| Nikita | Victor, nettoyeur | |||
| 1991 | Loulou Graffiti | Pique la Lune | ||
| L'Opération Corned-Beef | Capitaine Philippe Boulier, dit 'Le Squale'/Captain Philippe | |||
| 1992 | Kurenai no buta | Porco Rosso | Voice | |
| 1993 | La Vis | Monsieur K | ||
| Paranoïa | ||||
| Flight from Justice | Charlie Bert | TV | ||
| Les Visiteurs | Godefroy de Papincourt, Comte de Montmirail | |||
| 1994 | Léon (The Professional) | Leon | ||
| 1995 | Les Truffes | Patrick | ||
| French Kiss | Inspector Jean-Paul Cardon | |||
| Al di là delle nuvole | Carlo | |||
| 1996 | Mission: Impossible | Franz Krieger | ||
| Le Jaguar | Jean Campana | |||
| 1997 | Roseanna's Grave | Marcello | ||
| Un amour de sorcière | Molok | |||
| Les Soeurs Soleil | Un spectateur | |||
| 1998 | Les Visiteurs II: Les Couloirs du temps | Comte Godefroy de Montmirail, dit Godefroy | ||
| Godzilla | Philippe Roaché | |||
| Ronin | Vincent | |||
| 2000 | Les Rivières pourpres (Crimson Rivers) | Pierre Niemans | ||
| 2001 | Just Visiting | Count Thibault of Malfete | ||
| Wasabi | Hubert Fiorentini | |||
| 2002 | Décalage horaire | Felix | ||
| Rollerball | Alexis Petrovich | |||
| 2003 | Tais-toi! | Ruby | ||
| 2004 | Onimusha 3: Demon Siege (Capcom-based popular franchise) | Voice actor and Character Model of Jacques Blanc | ||
| Les Rivières pourpres II: Les anges de l'apocalypse (Crimson Rivers II: Angels of the Apocalypse) | Commissaire Niemans | |||
| Hotel Rwanda | Mr. Tillens (uncredited) | |||
| L'Enquête Corse | Ange Leoni | |||
| 2005 | L'Empire des loups (Empire of the Wolves) | Jean-Louis Schiffer | ||
| The Tiger and the Snow | Fuad | |||
| 2006 | The Pink Panther | Gilbert Ponton | ||
| Flyboys | Captain Thenault | |||
| The Da Vinci Code | Captain Bezu Fache | |||
| Flushed Away | Le Frog | voice | ||
| 2008 | Margaret | Ramon | awaiting release | |
| Ca$h | Maxime - Dubreuil | |||
| 2009 | The Pink Panther Deux | Gilbert Ponton | awaiting release | |
| Armored | Quinn | post-production |