Sometime in the 1870s Tissot met a divorcee, Mrs. Kathleen Newton, who became his companion and the model for many of his paintings. Mrs. Newton moved into Tissot's household in 1876 and lived with him until her suicide in the late stages of consumption in 1882 at the age of 28.
It was many years before he turned to the chief labor of his career - the production of a series of 700 water-color drawings to illustrate the life of Christ and the Old Testament. He disappeared from Paris, whither he had returned after the death of Kathleen Newton, and went to Palestine. In 1896 the series of 350 drawings of incidents in the life of Christ was exhibited in Paris, and the following year found them on show in London. They were then published by the firm of Lemercier in Paris, who had paid him 1,100,000 francs for them. (Over 500 related drawings, watercolors and oils are now in the collection of the Brooklyn Museum.)
The merits of Tissot's Bible illustrations lay rather in the care with which he studied the details of scenery than in any quality of religious emotion. He seemed to aim, above all, at accuracy, and, in his figures, at a vivid realism, which was far removed from the conventional treatment of sacred types.