She was brought to Hollywood for the film version of the latter, by Warner petite 4' 11" tall and with platinum blonde hair, Jewell appeared in a variety of supporting roles during the early 1930s. She played stereotypical gangster's women in such films as [[Manhattan Melodrama (1934) and Marked Woman (1937).
Her subsequent films included Gone with the Wind (1939) as "that white trash, Emmy Slattery", Northwest Passage (1940), High Sierra (1941), and the low budget The Leopard Man (1943) but by the end of the 1940s her roles had reduced in significance to the degree that her performances were often uncredited, e.g. Men in White (1934 – scenes deleted).
By the end of her career she had appeared in more than one hundred films, between 1930 and 1971. She also performed in radio dramas in the 1950s, including This is Your FBI.
Isabel Jewell played 'Susan's ' mother opposite Edie Sedgwick's biographical/drama based on the life of Edie Sedgwick life 'CIAO, Manhattan' by David Weismann just before the death of both actresses.
Isabel Jewell has a star on the Hollywood Walk of Fame for her contribution to motion pictures at 1560 Vine St.