I-235 is locally known as the MacVicar Freeway, in honor of two former mayors of Des Moines: John MacVicar Sr. (1896-1900, 1916-1918, 1928) and John MacVicar Jr. (1942-1948); the latter also served as the city's street commissioner in the 1930s. The name was adopted by the Des Moines city council in October 1963.
Interstate 235 in Iowa officially finished a major reconstruction in October 2007, though small construction projects are on-going, and the ends are still being reconstructed, particularly at the East Mixmaster.
| Location | Mile | # | Destinations | Notes |
|---|---|---|---|---|
| West Des Moines | I-235 continues west as I-80 (West Mixmaster Interchange). | |||
| 0 | 123A | – Kansas City | Western terminus; exit number is that of I-80 | |
| 0 | 123B | – Minneapolis, Chicago | ||
| 0 | 1A | 50th Street – West Des Moines | Westbound exit/eastbound entrance only | |
| 1 | 1B | Valley West Drive – West Des Moines | ||
| 2 | 2 | 22nd Street – West Des Moines, Clive | ||
| Windsor Heights | 3 | 3 | 73rd/8th Street – Windsor Heights, West Des Moines | |
| 3 | 4 | – Windsor Heights | ||
| Des Moines | ||||
| 4 | 5A | 56th Street | Westbound exit/eastbound entrance only | |
| 5 | 5B | 42nd Street | ||
| 6 | 6 | 31st Street – Terrace Hill Historic Site | ||
| 7 | 7A | MLK Jr Parkway, 19th Street – Des Moines International Airport | Westbound exits are combined as Exit 7. | |
| 7 | 7B | Keo Way – Bus Terminal | ||
| 8 | 8A | Downtown Des Moines, Iowa Events Center | ||
| 8 | 8B | East 6th Street, Penn Avenue | ||
| 9 | 9 | |||
| 10 | 10A | – State Fairgrounds | ||
| 10 | 10B | – East University Avenue | Eastbound exit/entrance only | |
| 11 | 11 | Guthrie Avenue | ||
| 12 | 12 | – Grand View College | ||
| Ankeny | 13 | 138A | , Kansas City | |
| 13 | 138B | Eastern terminus | ||
| I-235 continues north as I-35 (East Mixmaster Interchange). | ||||