A person who is undergoing immunosuppression, or whose immune system is weak for other reasons (for example, chemotherapy and HIV patients) is said to be immunocompromised. When an organ is transplanted, the immune system of the recipient will most likely recognize it as foreign tissue and attack it. The destruction of the organ will, if untreated, end in the death of the recipient.
In the past, radiation therapy was used to decrease the strength of the immune system, but now immunosuppressant drugs are used to inhibit the reaction of the immune system. The downside is that with such a deactivated immune system, the body is very vulnerable to opportunistic infections, even those usually considered harmless. Also, prolonged use of immunosuppressants increases the risk of cancer.
Cortisone was the first immunosuppressant identified, but its wide range of side effects limited its use. The more specific azathioprine was identified in 1959, but it was the discovery of cyclosporine in 1970 that allowed for significant expansion of kidney transplantation to less well-matched donor-recipient pairs as well as broad application of liver transplantation, lung transplantation, pancreas transplantation, and heart transplantation.
Dr. Joseph Murray of Harvard Medical School and chief plastic surgeon at Children's Hospital Boston from 1972-1985 was awarded the Nobel Prize in Physiology or Medicine in 1990 for his work on immunosuppression. Dr. Murray and his team are credited with first successful human kidney transplant at Peter Bent Brigham Hospital, Boston on 23 December 1954.
REEPITHELIALIZATION OF ORTHOTOPIC TRACHEAL ALLOGRAFTS PREVENTS REJECTION AFTER WITHDRAWAL OF IMMUNOSUPPRESSION
Apr 01, 2005; Prior work has demonstrated that immunosuppressed orthotopic tracheal allografts undergo progressive reepithelialization over a...