, a homoserine dehydrogenase
is an enzyme
the chemical reaction
- L-homoserine + NAD(P)+ L-aspartate 4-semialdehyde + NAD(P)H + H+
The 3 substrates of this enzyme are L-homoserine, NAD+, and NADP+, whereas its 4 products are L-aspartate 4-semialdehyde, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-homoserine:NAD(P)+ oxidoreductase. Other names in common use include HSDH, and HSD. This enzyme participates in glycine, serine and threonine metabolism and lysine biosynthesis.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes , , , and .
- BLACK S, WRIGHT NG "Homoserine dehydrogenase". J. Biol. Chem. 213 51–60.
- Starnes WL, Munk P, Maul SB, Cunningham GN, Cox DJ, Shive W "Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex". Biochemistry. 11 677–87.
- Veron M, Falcoz-Kelly F, Cohen GN "The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain". Eur. J. Biochem. 28 520–7.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes