Holy Cross is the largest Roman Catholic high school in the Lower Mainland with 780 students as of September 2006. Robert Dejulius has served as principal since the high school opened in 1982. Stan Kazun has served as vice principal also since the opening.
Sports events are held regularly at Holy Cross. The two major events held at Holy Cross are the Pepsi Bowl, which was founded by the school, and the BC Catholic Basketball Championship. This year at the BC Catholics, Holy Cross' girls team came in first place, and the boys team came in third. Also this year, the senior football team won the provincial championships.
Holy Cross's facilities include a full-sized wood floor gymnasium. They also include a track oval, and a football field. The track oval is open for public use.
The instrumental program includes two jazz bands and three concert bands, two jazz choirs and a concert choir.
At the 2008 Kiwanis music festival, Holy Cross' Concert Choir, Vocal Jazz, and Vocal Jazz II all received gold medals.
Also during 2008, the Grade 8 and 9 bands travelled to Whistler for a festival.
The Senior Concert Band travelled to New York City in 2008. The band performed in the plaza outside Lincoln Center, and the choir performed in St. Paul's Chapel and the lobby of the United Nations.
Past music groups from Holy Cross Regional High School have travelled to places such as Anaheim, Montreal, Banff, San Francisco, and Seattle.
As well, many Holy Cross Seniors take part in an annual Mission Trip. This trip brings the students to the Philippines where they work in Gawad Kalinga communities and help build homes for many underprivellaged families. They were the first school to ever come to the Philippines to help build homes.