HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Cw*1202 to *1215
Cw*1402 to *1405
Cw*1501 to *1511
Cw*1601 to *1606
Cw*1701 to *1703
Cw*1801 and *1802
HLA-C increases HIV-1 infectivity and is associated with gp120.(Research)(human leuckocyte antigens)(human immunideficiency viruses)
Aug 01, 2008; Authors: Andrea Matucci ; Paola Rossolillo ; Miriam Baroni ; Antonio G Siccardi ; Alberto Beretta ; Donato Zipeto...
Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C. (human leukocyte antigen-C)
May 21, 1993; Natural killer cells make up a subpopulation of about 10 to 15% of peripheral blood lymphocytes (PBLs) that lyse tumor and...