Giselle attended the Sacramento State University, where she graduated in 1982. Her television career began in 1983 at KRDO in Pueblo, Colorado. From 1985 until 1989, she worked as a television reporter and weekend anchor in Los Angeles (KTLA), Chicago (WBBM), and Miami (WCIX). While in Chicago, she met Ron Kershaw, who was previously involved with Jessica Savitch. The two were engaged, but Kershaw died of pancreatic cancer and liver cancer.
She gained her first national news job in October 1991 for CBS News, when she moved to New York and became a correspondent and back-up anchor for both the morning, evening, and weekend news broadcasts. She later moved to NBC, where she anchored the weekend edition of the Today Show and the Sunday NBC Nightly News, as well as various special reporting assignments in the U.S. and elsewhere.
From 1996 to 1999, Giselle was the co-host for Access Hollywood, an entertainment news program on NBC. She then co-hosted the "This Week in History" show on the History Channel. In 2002 she returned to her roots in Los Angeles and joined KTLA television news. She left this position in 2003 to pursue a variety of special projects, including making a movie and writing children's books.
Fernandez participated as a contestant on the second season of ABC's "Dancing With The Stars" in January 2006, but was the third contestant to be eliminated. She partnered with Jonathan Roberts and had an average of 23 points.