Born in Carrara, Italy, he fought in the assault troops during World War I. Later he emigrated to France, from where he returned to attempt the assassination of Benito Mussolini, Italy's Fascist Duce. On September 11 1926, in the Porta Pia square in Rome, he threw a bomb against Mussolini's car, but without effect.
Arrested, Lucetti stood trial in June 1927, and was condemned to life in prison. The politician Vincenzo Baldazzi was also condemned for having supported him in preparing the attempt.
In 1943 Lucetti escaped from prison with the help of others, but died shortly afterwards during a bombing of Ischia.