In the course of his career, Brisco wrestled for several National Wrestling Alliance (NWA) member promotions and won dozens of championships. Although, in the course of his career, he was largely overshadowed by his elder brother, former NWA World Heavyweight Champion Jack Brisco, he, along with Pat Patterson, achieved a degree of fame in the late 1990s and early 2000s as the onscreen "stooge" of WWE Chairman Vince McMahon.
During the spring break of 1968, Brisco was in Missouri with Jack, and was asked to substitute for his brother's injured tag team partner despite his lack of professional training. After Brisco contracted hepatitis and injured his knee, he decided to drop out of college and become a full-time professional wrestler.
The Briscos acquired a controlling interest (52%) in Georgia Championship Wrestling, and in 1984 they sold this share to Vince McMahon, enabling him to increase his dominance of the professional wrestling world. As a result, Gerald was given a lifelong job with McMahons's World Wrestling Federation. He retired soon after and began working backstage as a road agent and booker.
Following the 1997 Montreal Screwjob, Brisco capitalized on his notoriety by becoming an onscreen "stooge" of Vince McMahon along with Pat Patterson. The duo portrayed a pair of bumbling comic heels and joined The Corporation and the McMahon-Helmsley Faction. They lampooned Hulk Hogan (then working for World Championship Wrestling, the rival of WWF) by mimicking his trademark gestures and using "Real American," his old entrance theme.
On the May 18, 2000 episode of SmackDown! Brisco won his first WWF championship when he pinned a sleeping Crash Holly to win the perpetually contested Hardcore Championship. Crash regained the title on June 12, 2000 but Brisco was intent on regaining. He pursued Holly around New York City but ran afoul of John Shaft, who had agreed to protect Holly. Brisco eventually regained the title on June 19, 2000 with the aid of Pat Patterson in the midst of a match between Crash and his "cousin," Hardcore Holly. As Patterson and Brisco celebrated the victory, Patterson poured champagne in Brisco's eyes then broke a second bottle over his head. He then pinned the (kayfabe) unconscious Brisco to win the Hardcore Championship. Patterson hid from Brisco in drag in the women's locker room, and, after Brisco pursued him into the locker room, Vince McMahon booked them in a Hardcore Evening Gown Match at the King of the Ring on June 25, 2000. In the course of the match, Holly interfered and pinned Patterson, regaining the title once again.
Brisco remains an employee of the renamed World Wrestling Entertainment (WWE). He appeared at Wrestlemania 23 in a party scene and also on the July 23 edition of RAW. Brisco also owns a car garage with his brothers Jack and Bill, known as the Brisco Brothers Body Shop.
On July 15, 2005, Brisco was inducted into the George Tragos/Lou Thesz Professional Wrestling Hall of Fame.
On March 29, 2008, Brisco and his brother were inducted into the WWE Hall of Fame the night before Wrestlemania 24 in Orlando, Florida.