Tuska studied at the National Academy School of Art. In 1939, he became an assistant on the Associated Press newspaper comic strip Scorchy Smith, about an aviator. He also worked for comic book packager Eisner & Iger, "alongside Bob Powell, Lou Fine, and Mike Sekowsky" ,Tuska recalled, adding that the studio later expanded "with Charles Sultan, John Celardo, Nick Cardy, and [writer] Toni Blum joining in. I worked on 'Shark Brodie' [for Fiction House], 'Spike Marlin' [in Harvey Comics' Speed Comics, as "Carl Larson"], and other strips" for comics including Fiction House's Jungle Comics and Wings Comics, and Fox Comics' Wonderworld Comics and Mystery Men Comics.
Tuska later left to work with packager Harry "A" Chesler's studio, helping to supply content for such Fawcett Comics publications as Captain Marvel Adventures, and for such characters as Golden Arrow, Uncle Sam and El Carim. Tuska also drew the debut of the Quality Comics feature "Hercules" — starring a superhuman circus strongman, not the mythological figure — in Hit Comics #1 (July 1940).
Following Tuska's military service in World War II, he worked on Lev Gleason Publications' comic-book series Crime Does Not Pay, and later became one of the last writer-artists of Scorchy Smith, which ran until 1961. Tuska also did the comic strip Buck Rogers from 1959-1967.
Retired from active comics work, Tuska, as of the 2000s, lives in Manchester, New Jersey, and does commissioned art.
Tony Isabella: "I would love to see a Best of George Tuska collection which included his crime, mystery, romance, war, and western stories. He brought as much excitement and talent to those genres as he did to superhero comics".
Will Eisner on the early 1940s' Eisner studio: "It was a friendly shop, and I guess I was the same age as the youngest guys there. We all got along. The only ones who ever got into a hassle were George Tuska and Bob Powell. Powell was kind of a wiseguy and made remarks about other people in the shop. One day, George had enough of it, got up, and punched out Bob Powell".