Biletnikoff was born and raised in Erie, Pennsylvania to Russians who immigrated to the USA during the Russian Civil War. In Erie, Pennsylvania he attended what was then Technical Memorial High School and is now Central Tech. The Central Tech field is now named Fred Biletnikoff athletic field. His family later relocated to Panama City, Florida.
Biletnikoff was known as a wily, sure-handed receiver who made clutch catches to keep crucial drives alive. He had an uncanny ability to get open, even when everyone in the stadium knew that the ball was coming his way. He was famous for using liberal quantities of Stickum on his hands to improve his chances of catching a pass. He also tended to not wear any knee pads.
Biletnikoff's career total of 589 receptions is relatively unimpressive by today's standards, but it was a remarkable considering he would regularly smoke two packs of cigarettes per day. Also, this achievement is even more remarkable considering the more run-oriented offenses in the 60s and 70s, when the regular season was only 14 games long. The same can be said of his record of 10 straight seasons with 40 or more receptions. He played in the second AFL-NFL World Championship game and in Super Bowl XI, in which he was named MVP. In 1969, he was selected to the Sporting News AFL All-League Team. He also played in three American Football League title games, two American Football League All-Star games, five AFC Championships, and four AFC-NFC Pro Bowls.
On January 31, 2007 Biletnikoff retired as the wide receivers coach for the Oakland Raiders, which had been his role for 10 seasons. His retirement ended an 18 year coaching career with the Raiders.
Fred Biletnikoff Jr. is a Coach in the AF2 for Central Valley Coyotes .