A frameshift mutation causes the reading of codons to be different, so all codons after the mutation (with a few exceptions due to redundancy) will code for different amino acids. Furthermore, the stop codon "UAA, UGA, or UAG" will not be read, or a stop codon could be created at an earlier or later site. The protein being created could be abnormally short, abnormally long, and/or contain the wrong amino acids. It will most likely not be functional.
Frameshift mutations frequently result in severe genetic diseases such as Tay-Sachs disease. A frameshift mutation is responsible for the disabling of the CCR5 HIV receptor and some types of familial hypercholesterolemia (Lewis, 2005, p. 227-228). Frameshift mutations can also be beneficial.
Frameshifting may also occur during protein translation, producing different proteins from overlapping open reading frames, such as the gag-pol-env retroviral proteins. This is fairly common in viruses and also occurs in bacteria and yeast (Farabaugh, 1996).
New Findings Reported from University of California Describe Advances in Science.(frameshift mutation rates )
Jul 26, 2011; A report, "Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair,"...
Pantothenate kinase-associated neurodegeneration (PKAN): molecular confirmation of a Turkish patient with a rare frameshift mutation in the coding region of the PANK2 gene
Mar 01, 2009; SUMMARY: Cangül H, Özdemir Ö, Yakut T, Okan M, Morgan NV, Baytan B, Kurian MA, Spiegel R, Maher ER. Pantothenate...