Formamide, also known as methanamide, is an amide derived from formic acid. It is a clear liquid which is miscible with water and has an ammonia-like odor. It is used primarily for manufacturing sulfa drugs and synthesizing vitamins and as a softener for paper and fiber. In its pure form, it dissolves many ionic compounds that are insoluble in water, so it is also used as a solvent.
Formamide is also used as an RNA stabiliser in gel electrophoresis by deionizing RNA. In capillary electrophoresis, it is used for stabilizing (single) strands of denatured DNA.
Formamide, in its pure state, has been used as an alternative solvent for the electrostatic self-assembly of polymer nanofilms.
Formamide will begin to partially decompose into carbon monoxide and ammonia at 180°C. When heated strongly, formamide decomposes to hydrogen cyanide (HCN) and water vapor.
Formamide is highly corrosive in contact with skin or eyes and may be deadly if ingested. Inhalation of large amounts of Formamide vapor may require medical attention. Formamide should never be handled without proper safety attire including gloves and goggles.
Self-assembled coating for modification of the electro-osmotic flow in nonaqueous capillary electrophoresis using formamide.
Jul 01, 2007; Abstract: The use of pure nonaqueous solvents in capillary electrophoresis (CE) can alter the separation selectivity and enhance...
Determining the scalability of the one-pot synthesis of a novel formamide fungicide.(COMMUNICATIONS--UNDERGRADUATE)(Report)
Apr 01, 2008; Novel Formamide fungicides were designed by Bobylev et al as analogs of triazole fungicides were the triazole group was...