The area has a very large student population. The University of Manchester's main accommodation complex – the Fallowfield Campus – lies in its centre, and it also includes the university's Owens Park hall of residence.
Wilbraham Road is the site of the stylistically eclectic and, for its time, structurally innovative South Manchester Synagogue (1913).
The 1893 FA Cup final was played at Fallowfield Stadium, in which Wolverhampton Wanderers beat Everton 1-0, with Harry Allen scoring the only goal of the game. The stadium also hosted the cycling events for the 1934 British Empire Games, and the Amateur Athletic Association championships in 1897 and 1907. It was demolished in 1994, and the site is now Manchester University's Richmond Park Halls of Residence.
Fallowfield was the subject of the penultimate track on Manchester band The Courteeners debut album, St Jude, enititled "Fallowfield Hillbilly".
Fallowfield railway station was located on Wilmslow Road. What remains of the station building has been converted into a public house; the rest of the site is occupied by a Sainsbury's supermarket and a block of flats.