Ereshkigal received an entry in All-New Official Handbook of the Marvel Universe A-Z #4 (2006).
Ereshkigel was assigned by to investigate the City of the Space Gods, home of the Celestials, by Brother Tode, leader of the Deviants. She assumed a human appearance and boarded an airplane headed for the Andes mountains. The plane was captured by the Celestials, and brought into their hidden city for examination. However, another passenger on that plane was Don Blake, the secret identity of the Mighty Thor, as well as Ajak of the Eternals. Thor was able to easily overcome Ereshkigal. Thor turned her over to the custody of Ajak.
Later, she again took a human identity as H. D. Steckley (an alias formerly used by Moondragon), and schemed to get Quasar's power-bands. When she discovered the existence of an even more powerful artifact, the Star Brand, she attempted to acquire its might. Toward this end, she befriended Quasar's secretary Kayla Ballantine, who possessed the Brand, even becoming her roommate. When Kayla was recruited by an alien world to defend them from the Starblasters, "HD" went with her, and observed firsthand the power of the Star Brand, as Kayla easily destroyed a fleet of warships. They then returned to Earth.
The power of the Star Brand attracted the attention of Kismet, whom Kayla fought and seriously injured. Kayla, distraught, wished she didn't have the power anymore, and "HD" offered to take it. After the power was transferred, she then revealed her true self to a dismayed Kayla.
Ereshkigel flew to the pandimensional portal called the Nexus of Realities, easily defeating its guardian, the Man-Thing. She summoned the pantheon of powerful beings known as the Congress of Realities, and offered to overthrow the current guardians of the Multiverse and give free rein to the Congress. A few chose to follow her, and she destroyed the rest with her near-infinite power.
The cosmic guardian known as the Living Tribunal challenged Ereshkigel to a contest of champions, winner take all. Quasar and the Silver Surfer were chosen as champions; both were told the stakes involved, but not which side they represented. However, by observing the effects of their fight on the cosmic beings known as Master Order and Lord Chaos, Quasar was able to determine that he represented the side of Chaos, and allowed himself to lose. Defeated, Ereshkigal committed suicide, and the Living Tribunal took possession of the Star Brand.