Cakobau has been involved in politics; he was elected to the House of Representatives in 1999 as a candidate of the Fijian Political Party (SVT), representing the open constituency of Tailevu South Lomaiviti, and when the Conservative Alliance, a nationalistic political party was founded in 2001, Cakobau was chosen as its first president.
Cakobau is known as a devout Christian and has spoken forcefully about what he sees as the for the people to turn back to God. Speaking at the 150-year celebration of the building of the Nauluvatu church in the Nakelo district on 16 November 2005, he blamed the failure of the people to serve the Lord "vigilantly" for many of the problems being faced today He referred to the conversion to Christianity of his great great-grandfather, which he said was the best thing ever to have happened to Fiji, and that Fijians needed to return to those roots. "Blessings could only be received if we are on the right track with the church, vanua and the Government because if the people serve these institutions well, they should expect the blessings of their work," he said.
Personal Life: Has 3 siblings: 1.Adi Litia Kaunilotuma Cakobau 2. Ratu Josefa Celua Cakobau 3.Ratu Tanoa Visawaqa Cakobau
He also 2 half-sisters and a half-brother from his father's first marriage: 1: Adi Samanunu Talakuli nee Cakobau 2: Adi Litia Cakobau 3: Ratu George Kadavulevu
Ratu Epenisa Cakobau is married to Adi Varanisese Loloma the daughter of the late toranibau Ratu Josefa Loloma of Batiki,Lomaiviti and the late'''Adi Miriama Vuetivavalagi of Levuka Vakaviti,Ovalau it was an arranged marriage due to the close blood ties from both sides that had actually confirmed the matrimonial bonds between the two Vanuaeven before the two chief and chiefteness were born therefore it was meant to unite both land due to the ancestrol bonds Have 4 children : Ratu Popi Seniloli, Ratu Josefa Celua Cakobau; Adi Salote Cakobau & Ratu Tevita Naulivou
Ratu Epenisa also has children from outside of marriage.
2 sons: 1: Joseph Elliott 2: Christopher Cakobau 1 daughter : Adi Torika Kainona Cakobau