In 128, when she was 12, both she and her aunt were selected to be Emperor Shun's imperial consorts. (Emperor Shun was 13.) She was a favored consort, but she often declined offers to have sexual relations with the emperor, reasoning that an emperor needs to be equitable and give opportunities to other consorts.) Emperor Shun became impressed with her greatly. In 131, when he was considering creating an empress, he initially considered asking the gods for guidance and drawing lots from between four of his favorites, but after officials discouraged him from drawing lots, he considered Consort Liang most virtuous, so created her empress in early 132.
In 141, Liang Shang died, and Emperor Shun, in an ill-advised move, gave his position to Liang Ji. Liang Ji would, as the years go by, stamp out all dissent and position himself as the most powerful individual in the imperial administration.
Throughout her husband's reign, Empress Liang continued to be a favorite of Emperor Shun's, but she never bore a son for him. Emperor Shun was only known to have had one son -- Liu Bing (劉炳), born to Consort Yu in 143. In 144, as Emperor Shun was growing ill, he created the toddler crown prince. He died four months later, and Crown Prince Bing succeeded to the throne as Emperor Chong. Empress Liang, now empress dowager, served as regent.
In 145, the young Emperor Chong died, and in an effort to be open to people, Empress Dowager Liang announced his death openly immediately. She summoned the younge emperor's third cousins Liu Suan (劉蒜), the Prince of Qinghe, and Liu Zuan (劉纘), the son of Liu Hong (劉鴻) the Prince of Bohai, to the capital Luoyang, to be examined as potential successors. Prince Suan was probably an adult, and was described as solemn and proper, and the key officials largely favored him. However, Liang Ji wanted a young emperor whom he could control, so he convinced Empress Dowager Liang to make the seven-year-old Liu Zuan emperor (as Emperor Zhi). Empress Dowager Liang continued to serve as regent.
In 146, after the young Emperor Zhi showed signs that he was already cognizant of Liang Ji's corruption and offended Liang Ji by openly calling him "an arrogant general," Liang Ji had him poisoned, apparently without Empress Dowager Liang's knowledge. The key officials again largely favored Prince Suan as successor, but Liang Ji again vetoed their wishes, and instead persuaded Empress Dowager Liang to make the 14-year-old Liu Zhi (劉志), the Marquess of Liwu, who was betrothed to Empress Dowager Liang and Liang Ji's sister Liang Nüying, emperor (as Emperor Huan). Empress Dowager Liang continued to serve as regent.
In 147, Emperor Huan married Empress Dowager Liang's sister Liang Nüying and created her empress. Later that year, Liang Ji falsely accused Li Gu and Prince Suan of a conspiracy to start a military rebellion. Prince Suan was demoted to be Marquess of Weishi, and he committed suicide. Li, and another key official who opposed Liang Ji, Du Qiao (杜喬), were executed.
In 150, Empress Dowager Liang announced that she was stepping down as regent and returning imperial authorities to Emperor Huan. She died later that year and was buried with her husband Emperor Shun. However, Liang Ji remained in effective control of government and now, without his sister to curb his power, became ever more violent and corrupt. This eventually drew a reaction from Emperor Huan, who conspired with eunuchs to overthrow Liang Ji in a coup d'etat in 159. The Liang clan was slaughtered.