It was during this time that Whittemore began working on the novels for which he is probably best known. These constitute the Jerusalem Quartet, while another, earlier book titled Quin's Shanghai Circus (1974) contains the seeds of what was to come in the sequence. Out of print for many years, all five books were reissued by Old Earth Books in 2003.
Many writers and critics have lauded the novels' breadth and imaginative intensity in publications such as The New York Times Book Review, Harper's Magazine, The Nation, The Village Voice, Locus Magazine and The Magazine of Fantasy & Science Fiction. On the other hand, science fiction author and critic Thomas M. Disch gave Jerusalem Poker a very negative review in the Times Literary Supplement, bemoaning more enthusiastic appreciations as a "litany of avant-garde hype" while labelling Whittemore an "anti-writer" with a "genteel poverty of imagination."
In spite of all the enthusiastic reviews, the original editions failed to achieve the same degree of commercial success, and only about 3,000 hardcover and 10,000 paperback copies of each novel ever found a buyer. Whittemore was remarkably jealous about his privacy and refused to give interviews to "unknown correspondents," an attitude that somewhat hampered the promotion effort. His favourite word, "inscrutable," could also very appropriately be applied to him.
In 1982, Whittemore met American artist Helen Bar-Lev, and they lived together in Jerusalem for five years until he abruptly left her. During this time, Bar-Lev drew several sketches of Edward Whittemore and wrote a number of poems about him. 
Edward Whittemore spent the final years of his life in poverty, working as a photocopier at an attorney's office. He died in August 3, 1995 in New York City, shortly after being diagnosed with prostate cancer.