Born in West Springfield, Massachusetts, Wade received a limited schooling. He moved to Andover, Ohio, in 1821. He studied law. He was admitted to the bar in 1827 and commenced practice in Jefferson, Ohio. He was in the Justice of the Peace of Ashtabula County in 1831. He moved to Unionville in 1832. He served as prosecuting attorney of Ashtabula County 1833. He moved to Cleveland in 1837.
Wade was elected as a Free-Soil candidate to the Thirty-third Congress and reelected as a Republican to the Thirty-fourth, Thirty-fifth, and Thirty-sixth Congresses (March 4, 1853-March 3, 1861). He was not a candidate for renomination in 1860. He died in East Cleveland, Ohio, August 13, 1866. He was interred in Woodland Cemetery, Cleveland, Ohio.