When she dons her "Echo" guise, she is easily recognizable by a white hand stain which covers most of her face.
While still a young girl, Maya Lopez's father (known as Willie "Crazy Horse" Lincoln), was killed by the Kingpin. As Crazy Horse dies, he leaves a bloody handprint on Maya's face. His last dying wish is that his partner in crime, the Kingpin, raise Maya well: a wish the Kingpin honors, caring for her as his own.
Believed to be mentally disabled, Maya is sent to an expensive school for people with learning disabilities. There, she manages to completely replicate a song on the piano. She is subsequently sent to another expensive school for prodigies. She would soon become a gifted woman.
One day, upon visiting her father's grave with Fisk, Maya asks how he died. Fisk tells her that Daredevil killed him.
Matt Murdock and Maya soon fall in love. She later takes on the guise of Echo to hunt down Daredevil. On her face she paints a white handprint, similar to the bloody handprint left by her dying father. Having watched videos of Bullseye and Daredevil fighting, she proves more than a match for Daredevil. She takes him down and nearly kills him, refusing only when she finds out Matt and Daredevil are one and the same. Matt manages to correct the Kingpin's lies. In revenge, Maya confronts Fisk and shoots him in the face, blinding him and starting the chain of events that lead to his eventual downfall (Kingpin would later partially recover his eyesight through reconstructive eye surgery).
After realizing the horror of her actions and the lies she has grown up with, Maya flees the United States to do some soul-searching. When she comes back, she tries reuniting with Matt Murdock, only to find out he is now with a blind woman named Milla Donovan, and that the Kingpin is still alive (despite Maya's attempts to kill him). Leaving Matt, Maya visits the Kingpin in prison, who tells her that he doesn't blame her for what she did, and that despite all that had happened, he still loves her like a daughter.
Unsatisfied and still needing peace, Maya turns to the Chief, her father's old friend, noted for his wisdom. The Chief sends Maya on a Vision quest to calm her soul. On her quest, she meets and befriends Wolverine who helps her recover and passes on his knowledge of Japanese culture and Japanese organized crime. Soon enough, Echo makes peace with her past and is back doing performance art.
After joining the Avengers, Maya returns to Japan to keep an eye on Elektra Natchios, a dangerous assassin rumored to be leading the Hand, check on the Silver Samurai from time to time, and hopefully solve the conflict between The Hand and Clan Yashida. As Ronin, around the conclusion of the Civil War between the pro- and anti-registration factions in America, Maya fights Elektra and is killed, but is soon resurrected by the Hand with the same process used to raise Elektra. They take Maya captive with the intent of turning her into an assassin for The Hand. Luke Cage, Spider-Man, Wolverine, Doctor Strange, Spider-Woman, Iron Fist, and the new Ronin rescue her and escape, leaving a furious Elektra to send the Hand after them. During a brief lull in the fight with the Hand, in which Luke Cage tries to negotiate with Elektra to buy time, it is revealed that the Hand has been successful in brainwashing Maya, as she subsequently stabs Dr. Strange with a sword given to her by one of the Hand. She continues to fight the New Avengers until Dr. Strange is able to release his Astral Form, with Wong's help, and frees Maya from the brainwashing. Maya then charges straight for Elektra, who is fighting Luke Cage, and brutally stabs and slices her with a sword. It is revealed afterwards that Elektra is a Skrull warrior in disguise. They return to New York, after Spider-Woman's apparent betrayal of them when she steals the corpse of the Skrull Elektra. The Avengers hide in a hotel room, (Strange's magic making it appear that Echo is the only person in the room) before returning to Strange's Sanctum Sanctorum. Echo officially hands the Ronin identity over to Clint Barton after they arrive. After Strange confirms their identities by casting a spell that shows everyone their true nature- Echo appearing dressed in a female variation of Daredevil's costume- the team heads to Stark Tower to stop The Hood's attack on the building. There, they encounter the Mighty Avengers locked in battle with an army of invading symbiotes, one of which latches on to Echo before Iron Man manages to cure those infected.
In World War Hulk, Echo attempts to defend Rick Jones from Hiroim and Elloe of the Hulk's Warbound during their attack on the Sanctum Sanctorum to capture Doctor Strange. She, along with Iron Fist and Ronin, is defeated and captured.
After the defeat of The Hood's criminal organization, Echo remains on the team as Doctor Strange departs to the astral plane to heal himself, setting up base in a building owned by Iron Fist's company but technically leased to Samuel Sterns for the year. After a brief run-in with a Skrull disguised as Daredevil, Clint Barton admits being attracted to her, and the two begin a relationship.
Later, she encounters Spider-Woman, who is actually the Skrull Queen and the force behind the Invasion. "Spider-Woman" incapacitates Echo by repeatedly blasting her with venom blasts and then slams her into a nearby tree trunk. Echo helps the other Avengers kill all the other Skrull impostors, then heads to New York and confronts an army of Super Skrulls along with various other heroes and villains.
Although with great potential, deafness gives Maya Lopez great drawbacks. Her absolute reliance on visual cues renders her helpless in the dark, and her ability to communicate by reading lips prevents her from taking oral commands and communicating with people who are wearing masks or are not in direct visual contact; when she initially meets the Avengers, Captain America has to repeat all of Iron Man's questions for her. However, she has been incorrectly depicted as being able to hear and respond to voices despite not seeing the person's mouth due to standing away from them or the person talking right behind her .