Matthews was formerly head coach of the CFL's British Columbia Lions, Saskatchewan Roughriders, Baltimore Stallions, Edmonton Eskimos and Montreal Alouettes from whom he stepped down on October 4 2006 for health reasons. He was also head coach of the Orlando Thunder of the World League of American Football.
He is the winningest coach in the CFL with 231 wins.
In May, 2008, Matthews was announced as an advisor to the Jeff Hunt-led group's conditional Ottawa franchise.
Don Matthews returned to coach the Toronto Argonauts on September 9, 2008, after they started the season with a 4-6 record. In that press conference, Matthews revealed that the major health reason that caused him to step down as head coach of the Alouettes was an anxiety disorder. He also went further to say that he had been prescribed to some medication and the anxiety attacks are now under control.
Matthews' mother, Ida, was a francophone from Tracadie, New Brunswick, while his father, Fred, was from Prince Edward Island. Matthews has 3 sons and 6 grandchildren. In 2004, Matthews became a Canadian citizen.
He also has an additional 5 Grey Cup titles as defensive co-ordinator of the Edmonton Eskimos.
| Team | Year | Regular Season | Post Season | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Won | Lost | Ties | Win % | Finish | Won | Lost | Result | |||
| BC | 1983 | 11 | 5 | 0 | .688 | 1st in West Division | 1 | 1 | Lost in Grey Cup | |
| BC | 1984 | 12 | 3 | 1 | .800 | 1st in West Division | 0 | 1 | Lost in Conference Finals | |
| BC | 1985 | 13 | 3 | 0 | .813 | 1st in West Division | 2 | 0 | Won Grey Cup | |
| BC | 1986 | 12 | 6 | 0 | .667 | 2nd in West Division | 1 | 1 | Lost in Conference Finals | |
| BC | 1987 | 8 | 6 | 0 | .573 | 1st in West Division | - | - | (fired) | |
| TOR | 1990 | 10 | 8 | 0 | .556 | 2nd in East Division | 1 | 1 | Lost in Division Finals | |
| SSK | 1991 | 5 | 6 | 0 | .455 | 4th in West Division | - | - | Missed Playoffs | |
| SSK | 1992 | 9 | 9 | 0 | .500 | 3rd in West Division | 0 | 1 | Lost in Division Finals | |
| SSK | 1993 | 11 | 7 | 0 | .611 | 3rd in West Division | 0 | 1 | Lost in Division Finals | |
| BAL | 1994 | 12 | 6 | 0 | .667 | 2nd in East Division | 2 | 1 | Lost in Grey Cup | |
| BAL | 1995 | 15 | 3 | 0 | .833 | 1st in East Division | 2 | 1 | Won Grey Cup | |
| TOR | 1996 | 15 | 3 | 0 | .833 | 1st in East Division | 1 | 1 | Won Grey Cup | |
| TOR | 1997 | 15 | 3 | 0 | .833 | 1st in East Division | 1 | 1 | Won Grey Cup | |
| TOR | 1998 | 9 | 9 | 0 | .500 | 3st in East Division | 0 | 1 | Lost in Division Finals | |
| EDM | 1999 | 6 | 12 | 0 | .333 | 3st in East Division | 0 | 1 | Lost in Division Finals | |
| EDM | 2000 | 10 | 8 | 0 | .556 | 2nd in East Division | 0 | 1 | Lost in Division Finals | |
| MTL | 2002 | 13 | 5 | 0 | .722 | 1st in East Division | 2 | 0 | Won Grey Cup | |
| MTL | 2003 | 13 | 5 | 0 | .722 | 1st in East Division | 1 | 1 | Lost in Grey Cup | |
| MTL | 2004 | 14 | 4 | 0 | .778 | 1st in East Division | 0 | 1 | Lost in Conference Finals | |
| MTL | 2005 | 10 | 8 | 0 | .556 | 2nd in East Division | 2 | 1 | Lost in Grey Cup | |
| MTL | 2006 | 8 | 6 | 0 | .571 | 1st in East Division | - | - | (stepped down) | |
| TOR | 2008 | 0 | 5 | 0 | .000 | (Season still active) | - | - | (Season still active) | |