Dobutamine

Dobutamine

Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primarcy mechanism is direct stimulation of β1 receptors of the sympathetic nervous system. It was developed by a laboratory led by Dr. Ronald Tuttle at Eli Lilly & Company.

Use

Dobutamine is used to treat acute but potentially reversible heart failure, such as cardiac surgery or cases of septic or cardiogenic shock, on the basis of its positive inotropic action.

Dobutamine can be used in cases of congestive heart failure to increase cardiac output. It is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures. It is not useful in ischemic heart disease because it increases heart rate and thus increases the heart's demand for oxygen.

Pharmacology

Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to induce the release of norepinephrine (another α1 agonist), dobutamine is less prone to induce hypertension than is dopamine. Chronotropic, arrhythmogenic, and vasodilative effects are negligible.

Dobutamine is predominantly a β1-adrenergic agonist, with weak β2 activity, and α1 selective activity, although it is used clinically in cases of cardiogenic shock for its β1 inotropic effect in increasing heart contractility and cardiac output. Dobutamine is administered as a racemic mixture consisting of both (+) and (−) isomers, and the (+) isomer is a potent β1 agonist while the (−) isomer is a α1 agonist. Dobutamine also has mild β2 agonist activity.

Side effects

Primary side effects include those commonly seen for β1 active sympathomimetics, such as hypertension, angina, arrhythmia, and tachycardia.

References

Search another word or see Dobutamineon Dictionary | Thesaurus |Spanish
Copyright © 2014 Dictionary.com, LLC. All rights reserved.
  • Please Login or Sign Up to use the Recent Searches feature
FAVORITES
RECENT

;