In the early years of the magazine, the comics usually featured in the magazine were standard Disney-based comics such as DuckTales, Chip 'n Dale Rescue Rangers, TaleSpin, Darkwing Duck, Goof Troop, Gargoyles, Bonkers, and various adaptations of Disney feature films.
As the magazine evolved, non-Disney material from artists such as Sergio Aragonés, Evan Dorkin, Matt Groening, William Van Horn and Jeff Smith began appearing with some regularity. In addition, well known comic book industry names such as Marv Wolfman and Heidi MacDonald worked as comics editor for the magazine at various times during the mid-to-late 1990s.
Since 1998, Disney Adventures held the Annual Cool Pets Contest. The contest featured five of the "coolest" and most talented pets along with their owners.
In recent years, Disney Adventures included information on the Disney Channel and featured articles on current movies especially from Walt Disney Pictures. The magazine brings the features information on Walt Disney Parks and Resorts and features on music, movies, trends, science, travel, games, puzzles, heroes, explorers and real life adventures.
The Disney Adventures ceased publication ending with the November 2007 issue. For those with subscriptions, the Disney Adventures magazine is being replaced with Sports Illustrated Kids for the remainder of the subscription period. Some subscriptions have been proactively converted to Boys' Life magazine subscriptions, without any option for pro-rated refunds.
On August 21, 2007, Disney announced that Disney Adventures would be discontinued with the last issue cover dated November 2007, which was the magazine's 17th "birthday". The October 2007 edition contained a "Cool Christmas" subscription gift order form. Subscription readers were notified in January 2008 that their subscriptions will be transferred to Sports Illustrated for Kids on a 1 to 1 ratio. Disney expects to process subscription refunds in late February or March 2008.
Over the course of publication, a wide variety of comics professionals contributed to Disney Adventures Comic Zone section. Frequent contributors included: Garry Black, Alt Baltazar, Eric Jones, Matt Feazell, Landry Walker, Rick Geary, Evan Dorkin, John Green, Bob Fingerman, Elizabeth Watsin and Jeff Smith.