A special forces team must find a way to survive in a secret government facility that has been infested with time-displaced dinosaurs. It features similar gameplay to the Resident Evil series and promoted by Capcom as "panic horror".
It was later followed by two sequels, Dino Crisis 2 and Dino Crisis 3, and a light gun-based spinoff in Capcom's Gun Survivor series, known as Dino Stalker.
However throughout most of the premise, the player character is almost completely alone and must rely fully on collecting ammunition and security keys to gain access to new areas. The game also makes valuable good use of its sound effects which rise in tension when near an attacker.
Despite the fact that there are many enemies, the protagonist is not given a wide variety of moves at her disposal as most of Dino Crisis is labelled through text asking you on whether you wish to pick something up, climb up a ladder or to rappel up and down ventilation ducts. Because the game utilises survival horror elements, the player character will be attacked by enemies when you least expect it. This usually occurs when walking through mundane office environments where there are lots of obstacles.
The game does not really sport a physics engine as such since bullets will not make sufficient contact with walls or any other hard obstacles, but subtle elements of it are coveyed when shooting enemy dinosaurs.
They arrive onto the island via air infiltration (parachute). Cooper, however, is blown off course and ends up in a jungle. A Tyrannosaurus Rex appears and chases him a short distance before eating him. The other three agents, unaware of his death, proceed with the mission.
Once inside the base, they discover the mutilated and partially devoured corpses of security personnel and scientists. Shortly thereafter, they discover that dinosaurs (particularly velociraptors and compsognathus) are the reason behind the bloodbath at the base. After evading and disposing of many dinosaurs, and several near-escapes from a Tyrannosaurus Rex, Regina and the team manage to locate Dr. Kirk and apprehend him. As they are preparing to leave via helicopter, the T-Rex returns and destroys the helicopter forcing Regina and company to flee back into the base.
After interrogating Dr. Kirk, who reveals that the dinosaurs were brought to our time by an experiment he was running using his Third Energy Technology. A rift in space was created and a pocket of the island from our time was exchanged with the same pocket only from the past, thus bringing dinosaurs back into our time. As the base becomes infested with more dinosaurs, and the T-Rex manages to gain entrance, the team discovers an underground river and a hovercraft boat and manages to use it to escape before the Third Energy reactors (which were earlier set to overload by Regina) detonate, thus wiping out all the dinosaurs on the island and preventing them from escaping to the mainland.
The first ending (chase Dr. Kirk) results in Regina and Gail capturing Dr. Kirk. As a twist, Gail reveals that the whole mission was a front and the government did not want Dr. Kirk, but instead wanted the Third Energy to use in warfare. Gail gives Regina an optic disk containing all the data on the Third Energy. Shortly after, Gail dies from injuries suffered earlier in the game. Regina and Rick, during their departure in a watercraft, do battle with the T. Rex. Regina kills it using a remote explosive, and they escape with Dr. Kirk in custody.
The second ending (escape the island) results in Regina, Gail, and Rick escaping without Dr. Kirk. During the final T. Rex battle, Rick fires a rocket from a watercraft. The rocket hits a fuel tank, causing a massive overload in the Third Energy generator and completely disintegrating a portion of Ibis Island in the process. The three agents escape safely, but the status of Dr. Kirk is unknown.
The third ending is the 'good' ending; it can be achieved by choosing to leave Dr. Kirk, but actually going after him. Regina locates Dr. Kirk in a hangar, preparing a helicopter to get away in. She knocks Kirk out, and informs Rick of her situation. The T. Rex chases Rick and Gail to Regina's location. The three quickly board the chopper and flee from the T. Rex. During their escape, Rick drops a bomb from the helicopter onto the T. Rex, killing it immediately. All three agents get out alive with Dr. Kirk in tow.
The game keeps track of how many endings you have unlocked at the end of the game. After all three endings are found, the player unlocks Operation: Wipeout, a side game where the player must eliminate a set amount of dinosaurs in a certain time with limited ammunition.