Diffuse large B cell lymphoma - 3 reference results
Diffuse large B-cell lymphoma (DFBL) is a type of aggressive lymphoma. It accounts for approximately 40% of lymphomas among adults. Of all cancers involving the same class of blood cell, 31% of cases are DFBL.
Classification
Two major subtypes of DFBL have been identified based on their genetic activity:
- activated, with a pattern of genetic expression that is similar to healthy, activated B cells, and
- germinal center, with a pattern of genetic expression that is similar to germinal center B cells and a chromosomal translocation involving the gene bcl-2.
The remaining cases of DFBL are sometimes called "type 3," although they are unrelated to each other.
Chromosome anomalies are:
- t(14;18)(q32;q21) with BCL2-rearrangement,
- t(3;Var)(q27;Var) with BCL6-rearrangement,
- t(8;14)(q24;q32) with MYC rearrangements,
- and other less characteristic anomalies.
Treatment
Standard treatment is CHOP. An expanded protocol, called CHOP-R, has improved survival and rates of complete responses for DFBL patients, particularly elderly patients.Prognosis
The germinal center subtype has the best prognosis, with 60% of treated patients surviving more than five years.References
Wikipedia, the free encyclopedia © 2001-2006 Wikipedia contributors (Disclaimer)
This article is licensed under the GNU Free Documentation License.
Last updated on Wednesday August 06, 2008 at 11:33:59 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
This article is licensed under the GNU Free Documentation License.
Last updated on Wednesday August 06, 2008 at 11:33:59 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
Diffuse large B-cell lymphoma (DFBL) is a type of aggressive lymphoma. It accounts for approximately 40% of lymphomas among adults. Of all cancers involving the same class of blood cell, 31% of cases are DFBL.
Classification
Two major subtypes of DFBL have been identified based on their genetic activity:
- activated, with a pattern of genetic expression that is similar to healthy, activated B cells, and
- germinal center, with a pattern of genetic expression that is similar to germinal center B cells and a chromosomal translocation involving the gene bcl-2.
The remaining cases of DFBL are sometimes called "type 3," although they are unrelated to each other.
Chromosome anomalies are:
- t(14;18)(q32;q21) with BCL2-rearrangement,
- t(3;Var)(q27;Var) with BCL6-rearrangement,
- t(8;14)(q24;q32) with MYC rearrangements,
- and other less characteristic anomalies.
Treatment
Standard treatment is CHOP. An expanded protocol, called CHOP-R, has improved survival and rates of complete responses for DFBL patients, particularly elderly patients.Prognosis
The germinal center subtype has the best prognosis, with 60% of treated patients surviving more than five years.References
Wikipedia, the free encyclopedia © 2001-2006 Wikipedia contributors (Disclaimer)
This article is licensed under the GNU Free Documentation License.
Last updated on Wednesday August 06, 2008 at 11:33:59 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
This article is licensed under the GNU Free Documentation License.
Last updated on Wednesday August 06, 2008 at 11:33:59 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
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